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Mattes’ Mutual Information Metric for Multimodality Registration of DESS and T2 Mapped Knee Articular MR Sequences
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Registration of multiple MR sequences remains a challenging problem. The Insight Toolkit (ITK) implements the Mattes’ mutual information metric for multimodality registration. Here, example source code, data, and executable files to implement the Mattes’ [...]

Unsupervised Segmentation for Myofiber Counting in Immunofluorescent Microscopy Images
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The gold standard for measuring muscle regeneration in muscular dystrophy therapies is counting the number of dystrophin-positive muscle fibers on a cryostat muscle section immunostained for dystrophin. The standard process of manually counting a few thousand [...]

Creating a 2D Active Shape Model Using itk::ImagePCAShapeModelEstimator
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Although many variations of active contour segmentation algorithms exist, most are based on solely edge criteria and breakdown or leak at weak boundaries. One solution to this problem is constraining the segmented area to only statistically possible shapes [...]


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